The Human Thymus: Histophysiology and Pathology by B. von Gaudecker (auth.), Hans Konrad Müller-Hermelink

By B. von Gaudecker (auth.), Hans Konrad Müller-Hermelink (eds.)

Twenty-five years have handed when you consider that J. MILLER'S easy paintings at the imperative position of the thymus for the iteration of immunological reactivi­ ty. in this time, the abundance of interesting literature at the immunological and practical features of this organ has been unlike the paucity of news on its function in pathology. The causal or formal pathogenesis even of the various well-documented pathological fea­ tures is to date unexplained or not less than doubtful. even with a few concep­ tual growth regarding the paintings of CASTLEMAN, LEVINE, and ROSAI, we unfortunately need to say that during pathology the thymus continues to be nearly as inconspicuous as 25 years in the past. in simple terms the recent strategies constructed lately have made it attainable to appear as heavily into the complex structural association of the thymus because it seems to be essential to notice and record abnormalities. significant steps were keen on the appearance of mono­ clonal antibody immune histochemistry and with specified ultrastructur­ al reports in embryology. At this aspect, pathologists and researchers with a distinct curiosity within the thymus have been requested to offer overviews in their respective fields of curiosity in mild of contemporary findings in immunology and easy insights into the structural-functional interrelationship of the human thymus. the result of this initiative were introduced jointly during this volume.

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Extra resources for The Human Thymus: Histophysiology and Pathology

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3. Lightly stained epithelial cells scattered in the thymic medulla. These cells can become hypertrophic, synthesize bundles of tonofilaments, and give rise to the formation of the Hassall's corpuscles. Another type of epithelial cell has a more electron dense appearance with long slender processes. The more heterochromatic nucleus fits to the cellular forms, being spindle-shaped or cornered. This type of epithelial cell predominantly occupies the thymus medulla (Fig. 17 c), but some of them are found in the inner cortex.

H. SIEBKE, and Mrs. H. WALUK, and the skillful typing of the manuscript by Mrs. J. SCHLAHN. References Aarden LA (1979) Revised nomenclature for antigen-non-specific T-cell proliferation and helper factors. J ImmunoI123:2928-2929 Auerbach R (1961) Experimental analysis of the origin of cell types in the development of the mouse thymus gland. Dev Bioi 3:336-354 Badertscher JA (1914/15) The development of the thymus in the pig. I. Morphogenesis. II. Histogenesis. Am J Anat 17: 317-338, 437--493 36 B.

1981) Glucocorticoid sensitivity of splenocytes Controversial a KALIMI and BANERJI (1982) Aldolase activity of peripheral lymphocytes STEINHAGEN-THIESSEN and HILZ (1979) Levels of c GMP and cyclic adenosine 3' ,5' -monophosphate (cAMP) and cAMP IcGMP-ratios in resting peripheral T cells Controversial Increase Abs. and reI. number ofT cells in bone marrow a CALLARD and BASTEN (1977) Abs. number ofT cells in peripheral blood in healthy persons over 90 years HALLGRENet al. (1978, 1983) ReI. number ofT y cells in peripheral blood KISHIMOTO et al.

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