Targeting the IL-17 Pathway in Inflammatory Disorders by Cong-Qiu Chu

By Cong-Qiu Chu

This ebook offers an summary of the invention and constitution of IL-17, together with its pathogenesis and function in continual irritation and autoimmunity. To catch the most recent advancements and product approvals the booklet additionally discusses the healing advances and appears at rising treatments concentrating on the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key position in irritation, autoimmunity, and host protection in a couple of inflammatory problems resembling rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, a number of sclerosis, and inflammatory bowel sickness. the invention of the IL-17-Th17 pathway has visible intriguing improvement within the box of immunology and irritation learn, which has resulted in a few contemporary regulatory approvals.

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Aujla SJ, Chan YR, Zheng M, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med. 2008;14:275–81. 16. Prause O, Laan M, Lotvall J, Linden A. Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells. Eur J Pharmacol. 2003;462:193–8. 17. Witowski J, Pawlaczyk K, Breborowicz A, et al. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of 24 18. 19. 20. 21.

These results suggest a GM-CSF-driven positive feedback loop in operation in RA joints to perpetuate pathogenic Th17 cells. IL-21 is produced by natural killer (NK) cells and T cells. IL-21 signals through a unique IL-21R chain and the shared common γ-chain (shared by IL-2, IL-4, IL-7, IL-9, and IL-15). IL-21 is an autocrine growth cytokine for the expansion of Th17 cells. IL-21 together with TGF-α is able to induce the differentiation of Th17 cells, and IL-21 can replace IL-6 in this process [28].

Sahoo A, Alekseev A, Tanaka K, et al. Batf is important for IL-4 expression in T follicular helper cells. Nat Commun. 2015;6:7997. 91. Huber M, Lohoff M. IRF4 at the crossroads of effector T-cell fate decision. Eur J Immunol. 2014;44:1886–95. 92. Li R, Spolski W, Liao L, et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature. 2012;490:543–6. 1 Rheumatoid Arthritis Rheumatoid arthritis (RA) is characterized by chronic inflammation of the synovium and cartilage degradation and bone destruction.

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