Principles of Molecular Rheumatology (Current Molecular by George C. Tsokos

By George C. Tsokos

George Tsokos and a panel of authoritative clinicians and researchers synthesize the most recent findings from throughout cellphone and molecular biology with the fundamental rules of rheumatology to create the 1st textbook of molecular rheumatology. those tested specialists describe the biochemical mechanisms during which apoptosis, mobilephone signaling, supplement, lipids, and viruses give a contribution to ailment expression, and aspect either immune and nonimmune cellphone functionality in rheumatic illnesses. Their evaluate of the most important rheumatic illnesses integrates the mobile, biochemical, and molecular organic mechanisms which are very important in rheumatic ailment pathogenesis. Path-breaking and illuminating, rules of Molecular Rheumatology expands the envelope of scientific realizing to bare the organic roots underlying rheumatologic affliction, in addition to the character and roles of the robust new therapeutics now rising for its optimum therapy.

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Naturally, viral infections elicit potent antiviral immunity that may lead to crossreactivity against self-antigens. Analysis of molecular mimicries that is a delineation of autoantigenic epitopes of self-antigens may provide clues to the identity of viral antigens responsible for triggering the cross-reactive immune responses. Second, infection of genetically susceptible hosts by a potentially large number of commonly occurring viruses may lead to T- and B-cell dysfunction and autoimmunity. Immunoregulatory aberrations triggered by well-defined viral proteins at the level of antigen presentation, modulation of cytokine activities, and disruption of cell-death pathways, will be discussed.

Rheum. Dis. Clin. North Am. 24, 375–401. 5. , et al. (1998) Human parvovirus B19 as a causative agent for rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 95, 8227–8232. 6. , and Hedman, K. (1997) Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy [see comments]. Lancet 349, 1063–1065. 7. Phillips, P. E. (1997) Viral arthritis. Curr. Opin. Rheumatol. 9, 337–344. 8. Tingle, A. , Mitchell, L. , and MacWilliam, L. (1997) Randomised double-blind placebo-controlled study on adverse effects of rubella immunisation in seronegative women.

Natl. Acad. Sci. USA 89, 7742–7746. 97. , and Rickinson, A. (1993) Epstein–Barr virus-coded BHRF1 protein, a viral homologue of bcl-2, protects human B cells from programmed cell death. Proc. Natl. Acad. Sci. USA 90, 8479–8483. 98. Neilan, J. , Afonzo, C. , Kutish, G. , Sussman, M. , and Rock, D. L. (1993) An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the EpsteinBarr virus gene BHRF1. J. Virol. 67, 4391–4394. 99. Chou, J. and Roizman, B. 5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells.

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