New Concepts of a Blood—Brain Barrier by Michael W. B. Bradbury (auth.), John Greenwood, David J.

By Michael W. B. Bradbury (auth.), John Greenwood, David J. Begley, Malcolm B. Segal (eds.)

The medical contribution of Mike Bradbury to the examine of the blood-brain barrier is significant and wide-ranging, beginning along with his M.D. thesis in 1962 and nonetheless carrying on with this present day. the various spectrum of issues with regards to the blood-brain barrier offered during this quantity and the numerous geographical destinations from which either audio system and contributors collected to wait the symposium are a becoming testomony either to Mike's general effect within the box and to the esteem during which he's held. once we first had the belief of afestschrift to mark Mike's retirement as Professor of body structure at King's collage London and the start of a brand new vie libre as scientist and yachtsman the plan was once at the start for a meeting of the entire many colleagues, collaborators and scholars who had labored with him through the years. despite the fact that what we had now not taken into consideration used to be the closeness of the foreign neighborhood of employees within the box, the frequent impression that Mike had wielded and the rate with which observe may unfold. we must always have expected all 3. the ultimate final result was once an outstanding symposium with nearly all of the world's key employees both contributing or attending. we are hoping that this quantity provides an enough list of the meeting.

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New Concepts of a Blood—Brain Barrier

The clinical contribution of Mike Bradbury to the examine of the blood-brain barrier is significant and wide-ranging, beginning along with his M. D. thesis in 1962 and nonetheless carrying on with this present day. the various spectrum of themes when it comes to the blood-brain barrier provided during this quantity and the numerous geographical destinations from which either audio system and individuals accumulated to wait the symposium are a becoming testomony either to Mike's conventional impact within the box and to the esteem during which he's held.

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Bundgaard, Ultrastructure of frog cerebral and pial microvessels and their impermeability to lanthanum ions, Brain Res. 241:57 (1982). J. Le Beaux and J. Willemot, Actin-like filaments in the endothelial cells of adult rat brain capillaries, Exp. Neurol. 58:446 (1978). THE APPLICATION OF QUANTITATIVE IMMUNOCYTOCHEMISTRY FOR mE EVALUATION OF BWOD-BRAIN BARRIER (BBB) TO ENDOGENOUSALBUNUN Andrzej W. Vorbrodt Laboratory of Cytochemistry New York State Institute for Basic Research in Developmental Disabilities Staten Island New York 10314 USA INTRODUCTION In morphological studies of the permeability of blood microvasculature, various protein tracers have been used.

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1991. Correlation of zonula-occludens zo-I antigen expression atld tratlsendothelial resistatlCe in porcine atld rat cultured cerebral endothelial-cells. Neurosci. Letters 128:301-304. Kuban, K. C. and Gilles, F. H. 1985. Humatltelencephalic atlgiogenesis. AIIII. Neurol. 17: 539-458. , and Dcnnietzel, R 1994. The 140-kda protein of blood-brain barrierassociated pericytes is identical to atllinopeptidase-ll. J. Neurochem. 62:2375-2386. Leonhardt, H .. I980. ) pp. 177666, Springer-Verlag. LellIlg, D.

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