Gene Therapy in Inflammatory Diseases by Christopher H. Evans, Paul D. Robbins

By Christopher H. Evans, Paul D. Robbins

Gene remedy for inflammatory ailments is a brand new , burgeoning box of drugs. Edited via the undisputed pioneers of this quarter of study, this quantity is the 1st dedicated to its subject. It comprises 13 chapters, every one written by means of leaders of their respective fields, that summarize the cutting-edge in constructing novel, gene established remedies for inflammatory illnesses. in addition to delivering an creation to the elemental innovations of gene treatment and using bare DNA methods, the e-book describes the advances which were made in employing them to arthritis, lupus, a number of sclerosis, diabetes, Sjogren`s syndrome and transplantation.One bankruptcy is dedicated to discussing the 1st human medical trials that practice gene treatment to the remedy of an inflammatory sickness. in addition to offering novel healing techniques, gene treatment allows the advance of latest and better animal versions of sickness; a bankruptcy describing those advances is additionally integrated. As an updated, well timed publication written via th

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Makarov 15 Zvaifler N], Firestein GS (1994) Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 37: 783-789 16 Firestein GS (1996) Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum 39: 1781-1790 17 Fox DA (1997) The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. Arthritis Rheum 40: 598-609 18 Wilder RL, Remmers EF, Sano H, Case JP, Lafyatis R (1991) The cytokine network in rheumatoid arthritis.

Infusion. Another principal limitation of extraarticular transgene expression is that this approach is restricted to using secreted therapeutic genes and rules out delivery of intracellular inhibitors (such as inhibitors of transcription factors or cell-cycle inhibitors). Systemic in vivo gene transfer can be potentially improved by designing vectors with selective tropism and/or tissue-specific promoters affording a selective, local trans gene expression in the RA joints [84]. Systemic ex vivo gene delivery can be achieved by transducing circulating cells in vitro and re-injecting them into the circulation.

The extent to which activation of synovial T cells occurs prior to or following entry into the synovium is not yet known. Also largely unknown are the mechanisms regulating proliferation and apoptosis in the synovium and the role of cell-cell interaction between the major participants in the arthritic joint: macrophages, fibroblasts, chondrocytes, T and B lymphocytes, and dendritic cells. Gene transfer is uniquely capable of achieving local expression of exogenous molecules in the synovium, and thus affords addressing these questions.

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