Gastric Inhibitory Polypeptide by John Canvin Brown (auth.)

By John Canvin Brown (auth.)

Dr. Raymond Pederson, Dr. Jill Dryburgh and that i started out paintings on GIP in 1968, whilst, with the beneficiant support of Professor Viktor Mutt and Professor Erik Jorpes of the Karolinska Inst,itute, Stockholm, we have been capable of determine that there existed an inhibitory fabric for acid secretion in cholecystokinin-pancreozymin prepara­ tions. as soon as the physiological facts for the inhibitor used to be demonstrated it appeared applicable to hunt assist in its isolation. Dr. J. Dryburgh and Dr. R. Pederson have been left to bioassay fractions in Vancouver while I loved the corporate of Professor Mutt on the Karolinska for twelve months, as a clinical examine Council of Canada vacationing Scientist. Purification of the inhibitory issue proceeded quickly due, in no small degree, to Professor Mutt's untirmg efforts on my behalf. Later that yr, Dr. Dryburgh joined us in Stockholm to start the series paintings on GIP. This used to be accomplished overdue in 1970 in Vancouver. In Stockholm in June 1970, I met a fellow Canadian Dr. John Dupre (McGill college) at a dinner party who stored commenting in regards to the chance of GIP being an insulinotropic hormone, the "incretin" of past days. at the moment, gastrointestinal physiologist as i used to be, i didn't realize the significance of his remark. This turned obvious or 3 years later while Dr. Dupre established that GIP was once insulinotropic in guy. In 1972, Maryanne Kuzio and Dr.

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1979) when they studied the effects of a glucosidase inhibitor (BAY g 5421) on serum IRI, IR-GIP and glucose levels following ingestion of 75 g sucrose. Goulder et al. (1978) have demonstrated in diabetics that carbohydrate absorption can be delayed by increasing dietary fibre. A decrease in insulin requirement occurs as a result. Creutzfeldt et al. (1979) investigated the effect of the addition of guar to a liquid test meal on the release of IR-GIP in normal human volunteers. The IR-GIP response remained unchanged although there was a significant lowering of serum glucose and IRI.

A dose-response relationship was strongest for the effect of GIP on' the enzyme activity in extracts of acetone-ether powders of the ceils. Eckel et al. (1979) considered that the increased lipoprotein lipase activity produced by GIP could provide a mechanism for clearance of the triglyceride of chylomicron after feeding. c) Proinsulin Biosynthesis Proinsulin biosynthesis as measured by 3H-Ieucine incorporation and insulin secretion have been studied by Schafer and Schatz (1979) in collagenase-isolated rat pancreatic islets.

The change in serum IR-GIP was measured following ingestion of the triglyceride load, with and without an intravenous injection of insulin. When the insulin dose was administered, an intravenous infusion of glucose was also given to prevent hypoglycaemia. A bolus injection of insulin (7 mU) produced a transient elevation in plasma IRI and resulted in a significantly diminished plasma IR-GIP response to triglyceride ingestion. Brown et al. suggested that insulin was capable of inhibiting secretion of IR-GIP in normal man.

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