Frozen Section Library: Central Nervous System by Richard A. Prayson

By Richard A. Prayson

The Frozen part Library sequence offers concise, simple, website particular handbooks which are good illustrated and spotlight the pitfalls, artifacts and differential prognosis concerns that come up within the moved quickly frozen part state of affairs. Frozen part Library: primary fearful method is a handy, person pleasant guide to help within the overview of critical worried procedure comparable frozen sections. delivering an invaluable reference, equipped round differential diagnoses, basically through situation within the crucial anxious process, it's going to turn out a priceless software for the practising surgical pathologist either in neighborhood and in educational facilities in addition to pathology citizens and fellows in education while faced with Neuropathology frozen part. Richard A. Prayson, MD is on the division of Anatomic Pathology, Cleveland health center, Cleveland, OH Karl M. Napekoski, MD is on the division of Anatomic Pathology, Cleveland medical institution, Cleveland, OH

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A biopsy taken at the perimeter of the hemangioblastoma may show a markedly fibrillar background with mild hypercellularity and numerous Rosenthal fibers, which can lead one to consider a pilocytic astrocytoma diagnosis. This chronic gliosis finding is not uncommon around the perimeter of hemangioblastoma. 8). 18 Frozen Section Library: Central Nervous System Fig. 11 Brightly eosinophilic Rosenthal fibers may be seen in areas of gliosis. Once an assessment has been made as to location and whether the tissue being examined represents normal or gliosis or ­something else, the next question to ask is whether or not the lesion may possibly constitute a nonneoplastic process.

Patients who are immunocompromised are prone to develop lymphoma. Patients with a history of an organ transplant may develop a posttransplant lymphoproliferative disorder, which may look histologically ­indistinguishable from lymphoma at frozen section. In cases in which a history of transplantation is available, a diagnosis of posttransplant lymphoproliferative disorder is preferred, since not all of these processes behave like lymphoma. The vast ­majority of primary central nervous system lymphomas are diffuse large B cell lymphomas 24 Frozen Section Library: Central Nervous System marked by cells with an irregular nuclear contour.

Additionally, our experience with nonneoplastic lesions in the central nervous system is generally not as extensive as with tumors. Nonneoplastic central nervous system lesions can pose a significant differential diagnostic challenge and are often the source of considerable confusion and anxiety. 1). FLAG 1: CHRONIC VASCULAR-BASED INFLAMMATION Vascular-based chronic inflammation is not an uncommon finding at the time of frozen section. A subset of tumors, as is discussed later, may demonstrate perivascular chronic inflammation marked by benign appearing lymphocytes.

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