Endometrial Cytology with Tissue Correlations by John A. Maksem, Stanley J. Robboy, John W. Bishop, Isabelle

By John A. Maksem, Stanley J. Robboy, John W. Bishop, Isabelle Meiers

As in comparison with cytology's use in different organ platforms, direct cytological exam of the endometrium isn't really a largely practiced diagnostic strategy. This quantity highlights endometrial cytology as a good technique for making sure endometrial normalcy and studying and diagnosing malignant and premalignant states.

Endometrial Cytology with Tissue Correlations covers the heritage, assortment strategy, diagnostic standards and pitfalls, in addition to reliability of endometrial cytology.

This quantity, a part of the Essentials in Cytopathology booklet sequence, matches into the lab coat pocket and is perfect for portability and quickly reference. each one quantity within the sequence is seriously illustrated with a whole colour paintings software, whereas the textual content follows a straightforward define format.

John A. Maksem, M.D., is Director of Cytopathology, Orlando healthiness, Orlando, Florida.

Stanley J. Robboy, M.D., is Head of Gynecologic & Obstetrical Pathology, division of Pathology, Duke college scientific middle, Durham, North Carolina.

John W. Bishop, M.D., is HS medical Professor of Pathology, college of California, Davis, Sacramento, California.

Isabelle Meiers, M.D., is Head of Cytology at collage health facility Lewisham, London, United Kingdom.

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Additional info for Endometrial Cytology with Tissue Correlations

Sample text

Ishii Y, Fujii M. Criteria for differential diagnosis of complex hyperplasia or beyond in endometrial cytology. Acta Cytol 1997; 41: 1095–102. Kobayashi H, Otsuki Y, Simizu S, Yamada M, Mukai R, Sawaki Y, Nakayama S, Torii Y. Cytological criteria of endometrial lesions with emphasis on stromal and epithelial cell clusters: result of 8 years of experience with intrauterine sampling. Cytopathology 2008; 19: 19–27. Maksem JA. Performance characteristics of the Indiana University Medical Center endometrial sampler (Tao Brush) in an outpatient office setting, first year’s outcomes: recognizing histological patterns in cytology preparations of endometrial brushings.

1. A cell block (top) and brush cytology preparation (bottom) show the organization of the proliferative endometrial gland. The nuclei are tightly packed and pseudostratified. Apical mitoses are seen. The glands of proliferative endometrium replicate one another in size and in proliferative activity in that they are regularly regular. One of the subtlest keys to the cytological recognition of disordered proliferative states is up to threefold size variability between otherwise architecturally preserved glands.

During the early secretory phase, glands enlarge and display a moderate amount of well-defined, clear cytoplasm by which cell sheets and cells within glands begin to assume a honeycomb pattern. Also note that the nuclei appear rounder than those of proliferative endometrium. In the early portion of the mid-secretory phase, the extreme curvilinear nature of the gland is not yet well seen. Liquid-based cytology preparations do not show intraglandular secretory substance, but they reflect the cytoplasmic dominance that characterizes the normal mid-secretory phase.

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