Eicosanoids and other Bioactive Lipids in Cancer, by Anders Wetterholm, Martin J. Mueller, Martina Blomster,

By Anders Wetterholm, Martin J. Mueller, Martina Blomster, Bengt Samuelsson (auth.), Kenneth V. Honn, Lawrence J. Marnett, Santosh Nigam, Robert L. Jones, Patrick Y.-K. Wong (eds.)

Lipoxygenase: reports at the lively web site of Leuktriene A4 Hydrolase; A. Wetterholm, et al. PGH Synthase: Disruption of the Mouse Cyclooxygenase I Gene: features of the Mutant and components of destiny learn; R. Langenbach, et al. Alteration of Gene Expression: Characterization of Prostaglandin H Synthase-2 poor Mice and Implications for Mechanisms of NSAID motion; S.G. Morham, et al. Receptors: constitution and law of Platelet Activating issue Receptor Gene; T. Shimizu, H. Mutoh. irritation: PGE2 law of B Lymphocytes and T Helper 1 and T Helper 2 Cells: Induction of Inflammatory as opposed to Allergic reaction; E.R. Fedyk, et al. sign Transduction: Plasma Membrane Guanylate Cyclase: A Multimodule Transduction method; R.K. Sharma, T. Duda. Anandamide: Anandamide Amidohydrolase from Porcine mind: Partial Purification and Characterization; N. Ueda, et al. PAF: Cloning and Characterization of a Murine Platelet-Activating issue Receptor Gene; S. Ishii, et al. mobilephone progress and Apoptosis: medical stories: Poster periods: seventy six extra Articles. Index.

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5. In DU 145 cells, a deletion of 105 bp has been found in exon 21, which will lead to a short-size mRNA. Such a deletion is very likely to cause a dysfunction of the RB gene product 4. By polymerase chain reaction, a 103-bp-deletion of RB promoter sequences was identified in a small cell carcinoma of the prostate (mixed with adenocarcinoma) and loss of the regulatory sequences in the RB promoter has been demonstrated to alter RB gene expression and function 5. However, in another study such deletions have not been found in 23 cases of prostatic adenocarcinoma and one case of small cell carcinoma of the prostate 6.

Watson, A. , (1994), Calcium promotes Membrane Association of Reticulocyte 15- Lipoxygenase, Biochem. J. 298: 377. F.. , Heibein, l. , Charieson, S .. , (1993), 5-Lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes, J. Exp. Med. 178: 1935. , and Steinberg. D.. (1991), Gene expression in macrophage-rich human artherosclerotic lesions, J. Clin. Invest. 87: 1146 6 REGULATION OF 12-LIPOXYGENASE EXPRESSION BY EPIDERMAL GROWTH FACTOR IN HUMAN EPIDERMOID CARCINOMA A431 CELLS Wen-Chang Chang, Vi-Wen Liu, Ben-Kuen Chen and Ching-Jiunn Chen Department of Pharmacology College of Medicine National Cheng Kung University Tainan, Taiwan 70101 INTRODUCTION Arachidonate 12-lipoxygenase in the platelet was the first mammalian lipoxygenase discoverved'.

The cell preparations cultured in the presence of IL-4 did also show regular monocytes, but in addition numerous apoptotic cells. These cells were characterized by a shrunken and sometimes fragmented nucleus with condensation of the chromatin, vacuolated cytoplasm with otherwise intact organelles and intact cytoplasmic membranes (not shown). The number of apoptotic cells varied between 20-30%. The intracellular localization of the 15-lipoxygenase in IL-4 treated monocytes was similar to that found in A549 cells.

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