Deutsche Gesellschaft für Pharmakologie und Toxikologie: by (auth.)

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Extra info for Deutsche Gesellschaft für Pharmakologie und Toxikologie: Abstracts of the Autumn Meeting 10–14 September 1991, Berlin

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To date, the most comprehensive study of MDR in human tumors is that of Goldstein et al. (J. Natl. Cancer Inst. 81:116,1989) who analyzed over 400 tumor samples from a broad range of human malignancies. They found that many tumors from untreated cancer patients had relatively high mdr1 RNA expression. These tumors arose in organs with MDR as a normal component, including the liver, colon, and kidney. Such tumors are In chemotherapy. In ar~s~ng cooperation with several hospitals we investigated the expression of P-glycoprotein in more than 100 human tumors of different origin using immunohistochemical methods.

Supported in part by NIH grants R37 CA36401, POl CA20180, POl CA23099, P30 CA21765, a Center of Excellence grant from the state of Tennessee, and by ALSAC. S34 P-170 GLYCOPROTEIN AS A TUMOR RESISTANCE MARKER M. Volm A number of b~ochem~cal mechan~sms have been postulated to account for resistance to antineoplastic drugs. At present, of major investigational and therapeutic interest is the characterization of the multidrug-resistant phenotype and its clinical relevance (for review see Riordan and Ling, Pharmac.

Evans, Pharmaceutical Division, St. Jude Children's Research Hospital and Center for Pediatric Pharmacokinetics and Therapeutics, University of Tennessee, Memphis, USA 38101 Cyiotoxic anticancer drugs usually have a narrow therapeutic index, typically producing acute toxicity at dosages similar to those required for therapeutic efficacy. e. lack of efficacy). For drug-sensitive cancers where it is important to avoid underdosing cancer chemotherapy, more precise methods are needed to determine the optimal dosage in individual patients.

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