By G. W. Richter, Kim Solez
This two-volume set is a accomplished evaluation of the "in vivo" results in experimental animals brought on by means of numerous individuals of the cytokine relatives. The volumes clarify the pharmacological and toxico-pathological impact of such hematopoietic development elements as colony stimulating issue, the radical components IL-11 and stem phone elements. Then it summarizes the vast spectrum of job of a number of immunostimulatory assays (interleukins IL-1-IL-9) in traditional toxicological assays in addition to effects from transgenic types. The set additionally good points the inflammatory cytokines (IL-1, TNFa and beta, interfereon-g and TGF-beta) effectively reviewed by way of specialists within the box. The set reports the constitution and distribution of the membrane receptors for those progress components. It addresses the position of varied cytokines in disorder techniques (malaria, sepsis, and meningitis). Volumes 34A and 34B additionally hide the medical event with development components (interferons and GM-CSF), which sincerely convey that the preclinical facts have been predictive and useful for the clinician. every one quantity of "International evaluation of Experimental Pathology" includes an index, and every bankruptcy comprises references
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Additional info for Cytokine-Induced Pathology, Part B : Inflammatory Cytokines, Receptors, and Disease
Immunol. Immunopathol. 45, 348-355. , and Espevik, T. /. Exp. Med. 167, 1987-1992. , and Espevik, T. ( 1987). Lancet 1, 355-357. , and Taylor, B. A. ( 1 9 7 8 ) . / Immunol. 120, 422-424. In Vitro and in Vivo Activity and Pathophysiology of Human lnterleukin-8 and Related Peptides Roland Zwahlen Institut für Tierpathologie Universität Bern CH-3001 Bern 9, Switzerland Alfred Walz Theodor Kocher Institut Universität Bern CH-3001 Bern 9, Switzerland Antal Rot Sandoz Forschungsinstitut A-1235 Vienna, Austria I.
These renal changes were ob served primarily in the high-dose group. A minimal to mild proliferative nonsuppurative inflammatory lesion was present in the heart valves of most mid- and high-dose animals (Fig. 10). Very marked endosteal new bone formation was observed in all high-dose animals after 5 days of treatment (Fig. 11). This lesion was associated with hyperplasia of osteoblasts and increased formation of extracellular matrix (Fig. 12). Similar but milder bone changes were observed in some animals at the mid-dose level.
Table II. Nonclinical Toxicology Studies with rHuTGF-ß1 Acute toxicology Rat Intravenous Dermal Rabbit Intravenous Dermal Pilot multidose study (A293 cell material) Rat Intravenous, 14 days Subchronic toxicology Rat Intravenous, 4 weeks Dermal, 4 weeks Rabbit Dermal, 4 weeks was used, all studies were conducted with rHuTGF-ßl expressed in Chinese hamster ovarian (CHO) cells. II. EXPERIMENTAL RESULTS A. 0 mg/ml in 3% methylcellulose gel. In rats, the gel was applied to two wound sites, which were created using an 8 mm diameter Baker/Cumins biopsy punch, and in rabbits it was applied to a 2 cm x 2 cm surgical wound.