Comprehensive Cytopathology (4th Edition) by Marluce Bibbo, David C. Wilbur

By Marluce Bibbo, David C. Wilbur

This best-selling e-book will give you a entire advisor to the diagnostic purposes of exfoliative and aspiration cytology. The publication takes a systemic method and covers the well-known common and irregular cytological findings encountered in a specific organ. acceptable histopathological correlations and a attention of the potential differential analysis accompany the cytological findings.

The e-book is lavishly illustrated, making it the fitting useful source for day-by-day reference within the laboratory.

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Some centers use molecular assays such as OSNA to assess SLN without any morphological examination. There is some evidence to suggest that this technique can be applied in the neoadjuvant setting [49]; however sensitivity may be reduced [50], and it is not recommended as it precludes assessment of nodal response and is not calibrated to detect ITCs [6, 51]. of axillary lymph node status (ypT0ypNx). Current definitions, endorsed by the FDA for use in neoadjuvant clinical trials, require the absence of invasive disease in the breast and axillary lymph nodes, with or without the presence of DCIS (ypT0/isypN0 or ypT0ypN0).

2011;29:594–8. 69. Chen S, Chen CM, Yu KD, Zhou RJ, Shao ZM. Prognostic value of a positive-to-negative change in hormone receptor status after neoadjuvant chemotherapy in patients with hormone receptor-positive breast cancer. Ann Surg Oncol. 2012;19:3002–11. 70. Hirata T, Shimizu C, Yonemori K, Hirakawa A, Kouno T, Tamura K, et al. Change in the hormone receptor status following administration of neoadjuvant chemotherapy and its impact on the long-term outcome in patients with primary breast cancer.

50 % therapeutic effect but less than T-A T-C. <50 % therapeutic effect T-D. No therapeutic effect evident 1. No change or some alteration in tumor cells but no reduction in overall cellularity 2. Minor loss of tumor cells (up to 30 %) Chevallier [34] RCB [30] Miller-Payne [33] 3. 30–90 % reduction in cellularity 4. >90 % loss of tumor cells 5. No malignant cells identifiable. 2 × size + grade + LN stage Modified NPI [53] Sataloff [35] Breast Size categories as per TNM Tis carcinoma in situ. , CIS allowed) Association with DFS and OS [55, 56] Number of involved nodes and size of the largest metastasis N-B.

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