By Douglas D. Richman, Richard J. Whitley, Frederick G. Hayden
Informs scientists and healthiness care execs approximately all of the medically correct elements of this swiftly evolving box.
- Covers novel viruses, pathogenesis, epidemiology, analysis, remedy, and prevention.
- Addresses infections and syndromes concerning specific organ structures, in addition to the basics of contemporary clinical virology.
- Includes an important info on immune responses and vaccinology, diagnostics, antivirals, and the nascent box of gene treatment.
- Provides agent-specific chapters that aspect the virology, epidemiology, pathogenesis, scientific manifestations, and prevention and remedy of significant viral pathogens.
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Rapid antigen detection techniques are widely used, and the sensitivity of such techniques is dependent on the quality of the nasopharyngeal specimen, with nasopharyngeal aspirates superior to brushings or swabs (9). Their utility in routine management is unclear, although they may be useful for infection control purposes. Pathogenesis The pathophysiology of infectious bronchiolitis has been described most completely in the case of infection with RSV. The basic pathophysiological changes in bronchiolitis are summarized in Fig.
Henderson. 1983. Croup: an 11-year study in a pediatric practice. Pediatrics 71:871–876. 26. Department of Health and Human Services. 1994. Current estimates from the National Health Interview survey, 1992. DHHS publication no. (PHS) 94-1517. Department of Health and Human Services, Hyattsville, MD. 27. , R. J. Dockhorn, J. Grossman, J. C. Kisicki, M. Posner, M. A. Zinny, P. Koker, D. Korts, and M. T. Wecker. 1995. A dose-response study of the efﬁcacy and safety of ipratropium bromide nasal spray in the treatment of the common cold.
Clin. Infect. Dis. 42:518–524. 38. Falsey, A. R. 1998. Respiratory syncytial virus infection in older persons. Vaccine 16:1775–1778. 39. Falsey, A. , R. M. McCann, W. J. Hall, M. M. Criddle, M. A. Formica, D. Wycoff, and J. E. Kolassa. 1997. The ‘‘common cold’’ in frail older persons: impact of rhinovirus and coronavirus in a senior daycare center. J. Am. Geriatr. Soc. 45:706–711. 24 ■ VIRAL SYNDROMES AND GENERAL PRINCIPLES 40. Forni, A. , N. W. Schluger, and R. B. Roberts. 1994. Severe measles pneumonitis in adults: evaluation of clinical characteristics and therapy with intravenous ribavirin.