Classic Papers in Rheumatology by Paul Dieppe, Frank A. Wollheim, H. Ralph Schumacher

By Paul Dieppe, Frank A. Wollheim, H. Ralph Schumacher

Whereas an emphasis at the new is essential to any technological know-how, the relevance or significance of recent discoveries can't actually be favored with no robust experience of the framework of a self-discipline, and of the information that helped to form it. With this in brain, the editors of this ebook have tried to create a canon of texts that shaped the root of rheumatology. specialists at the analysis and administration of a number of the rheumatological stipulations have selected what they give thought to to be the foremost papers of their respective domain names. each paper is thoroughly defined and evaluated by way of its strengths, its weaknesses, and its contribution to the sector. Papers were selected that outline new illnesses or remedies, that experience replaced our entire frame of mind, or that experience easily stood the attempt of time. The editors wish that the papers profiled during this quantity will stimulate debate, inspire readers to search out the unique texts, and encourage the writers of the classics of the twenty first century.

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The fact that the material extracted from different tissues and nuclei reactive in the precipitation reaction was insensitive to deoxyribonuclease, ribonuclease and trypsin characterized it as clearly different from DNA and histone, but it also gave no line of identity in double-immunodiffusion with the other antigens. In contrast, there were lines of identity when a given serum (from patient Sm) was reacted with soluble extracts from tissues and nuclei of different origin and species. This indicated that the Sm antigen was widely distributed and immunologically identical between species.

Both in terms of titre as well as frequency, the most active sera were from rheumatoid arthritis (RA) patients, although 50 of 77 patients did not have the factor and sera from a few patients with non-rheumatic diseases also carried this activity. The activity was not associated with the sedimentation rate nor the presence of anti-streptococcal agglutinins and was thermostable to heating to 60°C for 30 min. The agglutination activating factor was contained in the globulin and not the albumin fraction of serum.

Related references (1) (2) (3) (4) (5) (6) (7) Larson A. Radiological grading of rheumatoid arthritis, an interobserver study. Scandinavian Journal of Rheumatology 1973; 2:136. Larson A, Thoen J. Hand radiography of 200 patients with rheumatoid arthritis after an interval of one year. Scandinavian Journal of Rheumatology 1987; 16:395–401. Larson A. How to apply the Larson score in evaluating radiographsof rheumatoid arthritis in longterm studies. Journal of Rheumatology 1995; 22:1974–1975. Kellgren JH, Lawrence JS.

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