Cerebral Ischemia and Dementia by M. D. O’Brien (auth.), Professor Dr. Alexander Hartmann,

By M. D. O’Brien (auth.), Professor Dr. Alexander Hartmann, Professor Dr. Wolfgang Kuschinsky, Professor Dr. Siegfried Hoyer (eds.)

In distinction to dementia of the Alzheimer sort, the topic of dementia next to cerebral ischemia has been mentioned quite not often. Now this publication offers a precis of the mind morphology, neurochemistry and scientific points of dementia next to cerebral ischemia. The contributions talk about the similarities and alterations among the 2 major dementia kinds. The large variety of points hide 1) the morphology and morphobiology of mind tissue in the course of getting older and less than the 2 pathological condi- tions, 2) the neuropathochemistry of put up mortem mind tissue of sufferers in addition to mind tissue from experimental animals, three) CSF adjustments in the course of getting older and in dementia states and four) scientific examine, generally utilizing mind imaging tech- niques to tell apart among dementia kinds and to discover a foundation for rational healing approaches.

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This thesis represents a modification of the idea advanced by Lashley, and was proposed specifically by Tomlinson et al. for some cases of cerebrovascular dementia. In the SDB, the analysis of infarct volume measured by CT as an individual variable was only weakly related to prevalent dementia, and did not survive the multivariate analysis. , who found a weak volume effect, but a strong association with brain atrophy in patients demented after multiple infarctions compared with nondemented patients with strokes or normal controls.

Yet, in our study the relationship was prominent, even when controlled for age. The simplest explanation might be that a proportion of patients had Alzheimer's disease prior to the stroke, and presented with two disorders causally unrelated at stroke onset. In these patients stroke merely complicated preexisting degenerative dementia, at least in the prevalent dementia cohort. This is suggested by the comparison of prestroke functional status between the demented and non demented groups. Impairment in function during the 1 month prior to the stroke was common in patients with prevalent dementia, a finding not explained by prior stroke.

In: Sarner M (ed): Advanced medicine no 18. Pittman, London, p 268 Starkstein S, Bolla-Wilson K, Robertson R (in press) The dementia syndrome of depression. In: Bornstein R, Brown GG (eds): Neurobehavioral aspects of cerebrovascular disease. Oxford University Press Oxford Tierney Me, Fisher RH, Lewis AJ et al. (1987) The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology 44: 131 Torvik A (1984) The pathogenesis of watershed infarcts in the brain.

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