Breast Pathology: Problematic Issues by Sami Shousha

By Sami Shousha

​This booklet covers functional diagnostic concerns in breast pathology, with targeted emphasis on components which pose diagnostic problems. those comprise facing the gross specimens derived from sufferers handled with conservative surgical procedure and people who had neo-adjuvant remedy sooner than surgical procedure. It additionally discusses the best way to take care of axillary lymph nodes, proliferative breast lesions, together with DCIS, and troublesome center biopsies, in addition to fibro-epithelial, spindle mobilephone, lobular, mucinous, metaplastic and papillary lesions, molecular type of breast cancers, breast lesions in male sufferers and breast immunohistochemistry. there's a concentrate on strange benign and malignant breast lesions and a good number of top quality photos aid the reader diagnose tricky cases.

Breast Pathology: complicated Issues is geared toward histopathology experts and senior trainees who take care of breast pathology.

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Extra info for Breast Pathology: Problematic Issues

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Some centers use molecular assays such as OSNA to assess SLN without any morphological examination. There is some evidence to suggest that this technique can be applied in the neoadjuvant setting [49]; however sensitivity may be reduced [50], and it is not recommended as it precludes assessment of nodal response and is not calibrated to detect ITCs [6, 51]. of axillary lymph node status (ypT0ypNx). Current definitions, endorsed by the FDA for use in neoadjuvant clinical trials, require the absence of invasive disease in the breast and axillary lymph nodes, with or without the presence of DCIS (ypT0/isypN0 or ypT0ypN0).

2011;29:594–8. 69. Chen S, Chen CM, Yu KD, Zhou RJ, Shao ZM. Prognostic value of a positive-to-negative change in hormone receptor status after neoadjuvant chemotherapy in patients with hormone receptor-positive breast cancer. Ann Surg Oncol. 2012;19:3002–11. 70. Hirata T, Shimizu C, Yonemori K, Hirakawa A, Kouno T, Tamura K, et al. Change in the hormone receptor status following administration of neoadjuvant chemotherapy and its impact on the long-term outcome in patients with primary breast cancer.

50 % therapeutic effect but less than T-A T-C. <50 % therapeutic effect T-D. No therapeutic effect evident 1. No change or some alteration in tumor cells but no reduction in overall cellularity 2. Minor loss of tumor cells (up to 30 %) Chevallier [34] RCB [30] Miller-Payne [33] 3. 30–90 % reduction in cellularity 4. >90 % loss of tumor cells 5. No malignant cells identifiable. 2 × size + grade + LN stage Modified NPI [53] Sataloff [35] Breast Size categories as per TNM Tis carcinoma in situ. , CIS allowed) Association with DFS and OS [55, 56] Number of involved nodes and size of the largest metastasis N-B.

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