Bone Marrow Pathology, Fourth edition by Barbara J. Bain, David M. Clark, Bridget S. Wilkins

By Barbara J. Bain, David M. Clark, Bridget S. Wilkins

Bone Marrow Pathology has been generally revised to mirror the numerous advances that have happened within the software of cytogenetics and specifically, molecular genetics within the prognosis, class and figuring out of haematological issues. This entire booklet not just presents details on all universal illness entities, but in addition covers infrequent problems within which bone marrow exam comes in handy. it truly is designed as sensible source with ‘Problems and Pitfalls’ sections all through to assist laboratory diagnosis.This fourth edition:Incorporates the thoughts of the 2008 WHO class of Tumours of Haematopoietic and Lymphoid TissuesCovers key diagnostic innovations akin to circulation cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysisIncludes new diagnostic algorithms and precis boxesContains 550 color illustrations together with fine quality electronic photomicrographs Haematologists and histopathologists will locate this publication a useful machine reference while appearing day-by-day blood and bone marrow investigations.

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Extra resources for Bone Marrow Pathology, Fourth edition

Sample text

In haematologically normal subjects, only small numbers of randomly distributed monocytes are present. Macrophages (Fig. 28) are identified as irregularly scattered, relatively large cells with a small nucleus and abundant cytoplasm. In thin sections, only the cytoplasm may be visible, the nucleus being out of the plane of the section. Phagocytosed debris may be prominent in the cytoplasm. Some are associated with erythroblasts (forming erythroblastic islands), plasma cells or lymphoid nodules.

Processing artefacts can be induced in bone marrow aspirates by inadequate drying of the film, poor fixation or prolonged storage of the film prior to TH E N OR M A L B ON E M A R R OW 41 Fig. 54 BM aspirate showing the effect of fixing and staining the film before adequate drying has occurred; the erythroblast nuclear content appears to have leaked into the cytoplasm. MGG ×100. Fig. 55 Vena cava scraping showing endothelial cells; similar cells are occasionally observed in BM aspirates. MGG ×100.

Br J Radiol, 59, 935–937. 17 Kansara G, Hussain M and Dimauro J (1989) A case of plasmacytoma in muscle as a complication of needle track seeding after percutaneous bone marrow biopsy. Am J Clin Pathol, 91, 604–606. 18 Fowler N, Asatiani E and Cheson B (2008) Needle track seeding after bone marrow biopsy in nonHodgkin lymphoma. Leuk Lymphoma, 49, 156– 158. 19 Bain BJ (2004) Bone marrow biopsy morbidity – report of 2003. Clin Lab Haematol, 26, 315–318. 20 Murphy WA (1977) Exostosis after iliac bone marrow biopsy.

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