Bone Marrow Pathology (3rd Edition) by Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget

By Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins

Written by means of one of many world's top haematologists, and 3 popular histopathologists, Bone Marrow Pathology presents a complete advisor to the prognosis of bone marrow sickness. Now in its 3rd version, the textual content has been greatly revised and rewritten to mirror the newest advances within the box.
Features:

An super functional, up to the moment textual content incorporating the hot WHO category of haematopoietic malignancies

A finished textual content written with nice precision and readability of style
Incorporates a brand new part 'Problems and Pitfalls' - a different part that would relief the operating pathologist confronted with a tough situation

An very important textual content for the haematologist, histopathologist and haematopathologist with equivalent weight given to peripheral blood, aspirate, trephine biology and really good techniques

Extensively illustrated with a few of the images being of paraffin-embedded sections

Combines all of the thoughts now utilized to bone marrow analysis, together with immunocytochemistry, movement cytometery, immunohistochemistry and the diagnostic function of cytogenetic and molecular genetic analysis

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Additional info for Bone Marrow Pathology (3rd Edition)

Example text

65 Trephine biopsy showing striated muscle which has been driven into the biopsy specimen: (a) H&E ×384; (b) reticulin stain ×384. Fig. 66 A hair follicle and ducts of a sweat gland which have been driven into a trephine biopsy specimen. H&E ×94. (b) 46 CHAPTER ONE (a) (b) Fig. 67 BM trephine biopsy showing sweat glands which have been driven into the biopsy. (a) Giemsa ×96. (b) Immunohistochemistry with an antibody to smooth muscle actin demonstrating the myoepithelial cells of the sweat gland.

4b). Haemosiderin inclusions in plasma cells are observed mainly in iron overload (for example in haemochromatosis and transfusional siderosis) and in chronic alcoholism [8]. Problems and pitfalls Since iron is distributed irregularly within bone marrow macrophages, it is necessary to assess a number of fragments before concluding that storage iron is absent or reduced. If necessary, a Perls’ stain can be performed on more than one bone marrow film. Stain deposit on the slide must be distinguished from haemosiderin.

On an MGG stain they are greenish-black (Fig. 4a). Their nature is confirmed by a Perls’ stain (Fig. 4b). Haemosiderin inclusions in plasma cells are observed mainly in iron overload (for example in haemochromatosis and transfusional siderosis) and in chronic alcoholism [8]. Problems and pitfalls Since iron is distributed irregularly within bone marrow macrophages, it is necessary to assess a number of fragments before concluding that storage iron is absent or reduced. If necessary, a Perls’ stain can be performed on more than one bone marrow film.

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