By W. A. Rudert, M. Trucco (auth.), Prof. Dr. med. W. A. Scherbaum, PD Dr. med. U. Bogner, Dr. med. B. Weinheimer, Prof. Dr. med. G. F. Bottazzo (eds.)
Current wisdom appropriate to the knowledge of thyroid autoimmunity is summarized during this ebook. a number of the world's top scientists during this box evaluate contemporary facts from 4 topic parts: immunogenetics, thyroid peroxidase as an antigen, environmental components, and cytokines. a lot ongoing and as but unpublished paintings is defined, in particular within the dialogue integrated after each one article. this data is of specific curiosity because the physique of data in those fields is turning out to be very swiftly. The booklet relies on a workshop during which researchers from thirteen nations took half. One significant goal was once to elevate arguable issues and to strengthen rules for his or her power resolution. on the workshop it turned obvious good deal of the data given in textbooks is outmoded. this is often an immense replace for researchers who're drawn to the above issues and in figuring out the etiology and pathogenesis of thyroid autoimmunity.
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Extra resources for Autoimmune Thyroiditis: Approaches Towards its Etiological Differentiation
N 0body has found any exceptions from published sequences. If you sequence a DQw7 sequence yourself, you will confirm the published sequence. Nobody has found a mutation in these sequences so far in patients; if you look at rheumatoid patients or at diabetic patients, they fit the published sequences. Trucco: But that is not correct because there exists a RFLP with the enzyme A CYY that is recognized in a patient in position 57 of the second exon recognizing exactly the aspartic acid or not the aspartic acid.
Discussion Both subacute (de Quervain's) and Hashimoto's thyroiditis involve inflammation of the thyroid gland. In de Quervain's thyroiditis there is disruption of the follicular structures with extensive epithelial destruction including the formation of histiocytes. In Hashimoto's thyroiditis - the first human autoimmune disease in which an auto antigen-autoantibody reaction was described in 1956 be Roitt and coworkers [8, 9] - a lymphocytic infiltration and slight fibrosis can be seen. It is a striking feature of such diseases that they are associated with certain alleles of the class I and class II molecules of the HLA complex.
Nature 329: 512-517 16. Klein J (1986) Natural history of the major histocompatibility complex. Wiley, New York 17. Duquesnoy RJ, Trucco M (1988) Genetic basis of cell surface polymorphisms encoded by the major histocompatibility complex in humans. Crit Rev Immunol8: 103-145 18. Bertrams J, Baur M (1984) Insulin dependent diabetes mellitus. In: Albert ED, Baur MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg New York, pp 348-356 19. Schreuder G, Tilanus M, Bontrop R, Bruining J, Giphart M, Van Rood J, DeVries R (1986) HLA-DQ polymorphism associated with resistance to Type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction length polymorphisms.