Atlas of the Liver by Joseph R. Bloomer, Hiba Risheg (auth.), Willis C. Maddrey

By Joseph R. Bloomer, Hiba Risheg (auth.), Willis C. Maddrey MD, MACP (eds.)

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Some geographic variation was also present. ) Acute Viral Hepatitis WPM ................. HISTOLOGY . ............ . fiGURE 2-38. Typical biopsy findings in viral hepatitis. Diffuse hepatocellular necrosis with marked histiocytic reaction and infiltration with polymorphonuclear cells and mononuclear cells. Areas of necrosis and inflammation are intermingled. Hematoxylin and eosin. (Courtesy of Z. ) REFERENCES 1. : Incidence and risk factors for acute hepatitis Bin the United States, 1982- 1998: implications for vaccination programs.

The virion is then uncoated and the capsid is transported to the nucleus. In the nucleus, the capsid is disassembled, and the open circular HBV DNA is released. The second strand is completed, and the strand ends are ligated, resulting in the production of covalently closed circular DNA (cccDNA), which serves as the template for transcription of the virus into viral RNAs, which are transported to the cytoplasm. Translation of the messenger RNA (mRNA) results in the production of the precore, envelope proteins, and the core protein.

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