Amebiasis: Biology and Pathogenesis of Entamoeba by Tomoyoshi Nozaki, Alok Bhattacharya

By Tomoyoshi Nozaki, Alok Bhattacharya

This ebook files and provides new advancements within the research of amebiasis, one of many overlooked tropical ailments. approximately 50 million humans around the world are contaminated with the pathogen Entamoeba histolytica, inflicting large-scale morbidity and mortality rather in constructing nations. This publication can assist clinicians for greater prognosis and administration of the disorder, researchers for starting up learn tasks on many of the poorly understood facets of the sickness and the pathogen, and scholars for updating their wisdom. the themes lined diversity from genomics and molecular and cellphone biology to drug resistance and new drug improvement, highlighting significant advances in recent times in our knowing because of fast development in genomic and different biomedical applied sciences, similar to visualization of molecular methods. many of the chapters supply fresh info in response to most modern courses. a couple of chapters describe many of the severe methodological matters that might be useful for college students and researchers drawn to stepping into the sector. The contributing authors contain just about all the lively researchers and clinicians from world wide. This booklet might be an invaluable basic fabric and a precious resource of data for a person attracted to realizing amebiasis, its prognosis, and therapy. it's going to even be valuable to people who have an interest in studying concerning the biology of early branching eukaryotes and protist pathogens.

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The approach taken was whole chromosome shotgun sequencing (WCS), in which chromosomes were separated by pulsed-field gel electrophoresis (PFGE), isolated, and shotgun Sanger sequenced [43], undertaken in combination with HAPPY mapping to guide the sequence assembly. This combination of physical mapping and sequencing allowed assembly of the six chromosomes of the D. discoideum genome, totaling approximately 34 million bases. Unfortunately, the molecular karyotype of E. histolytica appears to be particularly complex.

Histolytica and can infect nonhuman primates [25]. 3 The Genomics of Entamoebae: Insights and Challenges 29 Fig. 1 Phylogenetic position and diversity of Entamoeba. a Phylogenetic topology of the evolutionary position of Entamoeba, showing the divergence of the Amoebazoa (containing Entamoeba, Mastigamoeba, and Mycetozoa) from the opisthokonts (animals and fungi) after the divergence of the plants. Also shown are the relative positions of other protists: the alveolates (including Plasmodium), kinetoplastids (including Trypanosoma and Leishmania), and diplomonads (including Giardia).

Brumpt E (1925) Étude sommaire de l’ “Entamoeba dispar” n. sp. Amibe à kystes quadrinucléés, parasite de l’homme. Bull Acad Méd (Paris) 94:943–952 7. Brumpt E (1928) Differentiation of human intestinal amoebae with four-nucleated cysts. Trans R Soc Trop Med Hyg 22:101–114 (discussion 115–124) 8. Brumpt E (1936) Précis de parasitologie. Masson et Cie, Paris 9. Simic T (1931) Présence de l’Entamoeba dispar Brumpt dans le sud de la Yougoslavie (Macédoine Serbe). Ann Parasitol Hum Comp 9:289–302 10.

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