Addressing the Threat of Drug-Resistant Tuberculosis: A by Institute of Medicine

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Extra info for Addressing the Threat of Drug-Resistant Tuberculosis: A Realistic Assessment of the Challenge: Workshop Summary

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The editorial argued that the world lacked proper drugs, diagnostics, and strategies for combating the disease (Bloom and Murray, 1992). Today the world stands on the precipice of a TB pandemic, the full extent of which is not known, and Farmer argued that the tools needed to combat the problem are still lacking. organization of this report This report is intended to provide a faithful summary of the presentations and discussions that took place during the workshop, although remarks have been substantially abbreviated and reorganized to improve the report’s readability and usefulness.

Estonia’s notification rate for TB is decreasing, and the percentage of MDR TB is decreasing slightly. Although the TB notification rate in Tomsk is decreasing as well, the percentage of MDR TB among new cases is rising. These data demonstrate that investments in TB control alone will not be sufficient to combat the problem and that new drugs will be needed.  The samples analyzed had been collected, tested for resistance to at least three second-line drugs, and stored. S. National Surveillance System (collected during 1993–2004); samples taken from a cohort of MDR TB patients in Latvia’s National MDR TB Registry during 2000–2002; and samples from South Korea’s National Reference Laboratory.

Copyright 2008 WHO, reprinted with permission from WHO, 2008b. < 3% 3–6% > 6% No data 26 27 THE GLOBAL SPREAD OF TUBERCULOSIS Table 2-2). He suggested that the rifampicin argument is also invalid. For example, Mozambique introduced rifampicin roughly 10 years after South Africa, yet Mozambique’s MDR TB rate is already higher than South Africa’s. In addition, the MDR TB rate in Mozambique, which introduced rifampicin at the same time as Gambia, is 10 times higher than that in Gambia. Ben Amor further argued that countries identified as having the capability to conduct drug resistance surveys (WHO, 1997, 2000, 2004, 2008b) are more likely to have a well-functioning national TB program, laboratory structure, and transport network and therefore lower rates of MDR TB than those countries without these capabilities.

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