Abstracts-233rd ACS National Meeting by ACS

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These data suggest that the presence of the hydroxyl group in fluconazole is critical for generating maximal antifungal activities. MEDI 61 Optimizing the synthesis of N-methanocarbathymidine, a potent and selective antiviral agent Victor E. gov, and Olaf R. 0]hexane template locked in the northern conformation. Nucleosides based on this scaffold were originally introduced to investigate the conformational preferences of kinases and polymerases. However, some conformationally restricted nucleosides also showed interesting antiviral properties.

Edu Estradiol is a high affinity ligand for estrogen receptor (ER) and we have synthesized several estradiol conjugates of carboranes derived from Baylis Hillman reaction as potential targeted agents for ER positive breast cancers. Rapidly growing cancer cells consume large quantities of cholesterol for the cell membrane biosynthesis. Cholesterol conjugates of carboranes were also synthesized as targeted agents for cancer chemo-, radiotherapeutic, and diagnostic agents for brain tumor. Synthesis and biological evaluation of several of these molecules will be presented.

Employing the above route, and utilizing easily available nucleobases and amino acids as two diversity elements, synthesis of a twentyfourmembered combinatorial library of the title nucleosides have been accomplished. The details of the synthesis will be presented. com, and Ye Yanrui, College of Bioscience and Bioengineering, South China University of Technology L-A helper virus and M1 satellite virus in S. cervisiae T158c/S14a were used to detect small variations in programmed ribosomal frameshifting (PRF) which was a typic mechanism for many classes of RNA viruses to express multiple protein.

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